Is Biote Hormone Treatment Safe? A Look at the Research and Results

Written by OC Wellness Physicians  »  Updated on: April 24th, 2025

Is Biote Hormone Treatment Safe? A Look at the Research and Results

Introduction

Hormone changes might be the reason. Many people turn to hormone replacement therapy (HRT) to feel better, and one popular option is called Biote hormone treatment.

Before starting any treatment, it’s important to ask: Is it safe? In this blog, we’ll explain what Biote therapy is, what the research says about its safety, and what real people have experienced while using it. Let’s find out if Biote could be a safe choice for you.

Understanding Biote Hormone Therapy

Biote hormone therapy is a type of treatment that helps balance your hormones using something called bioidentical hormones. These hormones are designed to closely resemble the ones your body makes on its own.


Biote delivers hormones to your body in tiny pellets, roughly the size of a rice grain. A doctor places the pellet just under your skin, usually near your hip. Once it’s in, it slowly releases hormones over time, helping you feel better without big highs and lows.


This method is different from pills, patches, or creams. It offers a more steady flow of hormones, which may help improve your mood, energy, sleep, and more.


The Science Behind Biote: What the Research Says

Biote hormone therapy is backed by research that shows it can be an effective way to help balance hormones, especially in people experiencing symptoms of hormone imbalance, like fatigue, mood swings, or sleep issues.


Studies on bioidentical hormone replacement therapy (BHRT) — the type of therapy Biote uses — suggest that it’s often a safer and more natural option compared to traditional synthetic hormone treatments. This is because bioidentical hormones are chemically identical to the ones your body produces, which may help reduce side effects.


Several studies have shown that patients who use Biote experience improvements in energy, mood, and sleep. The steady release of hormones from the pellets helps keep levels consistent, which avoids the sharp ups and downs that can happen with other forms of hormone therapy, like pills or patches.


While research supports the benefits of Biote, it’s important to work with a healthcare provider to determine if it’s the right choice for you.

Reported Benefits of Biote Therapy

Many people who use Biote hormone therapy say they feel a big difference in their overall well-being. Biote may help you feel better every day because it helps you regain equilibrium in your hormone levels.


Here are some of the common benefits people report:

  • More Energy: Many patients say they feel less tired and have more energy to get through the day.
  • Better Sleep: With balanced hormones, it's often easier to fall asleep and stay asleep through the night.
  • Improved Mood: People often notice they feel calmer, more focused, and less anxious or irritable.
  • Increased Libido: A healthy hormone balance can lead to a better sex drive and improved intimacy.
  • Weight Control Support: Some find it easier to maintain or lose weight with balanced hormones.
  • Mental Clarity: Hormone balance can reduce brain fog and help improve memory and focus.

Keep in mind that every person is different. Some notice changes quickly, while for others, it may take a few weeks. The key is working with a trained Biote provider who can adjust your treatment as needed.


Safety Profile and Potential Risks

Biote hormone therapy is considered safe for many people, especially when given by a trained provider who closely monitors your hormone levels. However, it does have some risks and adverse consequences, just like any other medical treatment.


Common Side Effects

Some people may experience mild side effects when starting Biote, such as:

  • Redness or bruises where the pellet was inserted
  • Bloating or fluid retention
  • Acne or oily skin
  • Mood changes or headaches

Usually transient, these adverse effects disappear as your body adapts.

Less Common but Serious Risks

In rare cases, hormone therapy can lead to more serious issues, such as:

  • Increased risk of blood clots
  • Breast tenderness or changes
  • Worsening of hormone-sensitive conditions (like certain cancers)

That’s why it’s so important to have your medical history reviewed and to work with a provider who knows how to properly balance hormone levels.


Who Should Avoid Biote Therapy?

Biote may not be right for you if you:

  • Are pregnant or breastfeeding
  • possess a history of specific cancers, such as prostate or breast cancer.
  • Have liver disease or blood clotting disorders
  • Are not able to have regular follow-ups with a provider

Always talk to your healthcare provider before starting any hormone treatment. 

What Experts and Medical Providers Say

Medical professionals have mixed opinions about hormone replacement therapy, but many support Biote when it’s used carefully and with the right patients.

Doctors who specialize in hormone health often say that bioidentical hormones, like the ones used in Biote, are a good option because they closely match the hormones your body naturally produces. This can lead to fewer side effects and better results for some people.

Many healthcare providers appreciate that Biote uses a customized approach. Before starting treatment, patients take a blood test to check their hormone levels. Based on the results, the provider creates a plan that fits the patient's needs. This personalized care is one reason some experts prefer Biote over one-size-fits-all treatments.

Professional groups, like the American Academy of Anti-Aging Medicine, support the careful use of bioidentical hormones. However, some larger medical organizations recommend more research, especially for long-term use.

Most providers agree on one thing: Biote therapy should always be done under medical supervision. Working with a certified Biote provider is key to staying safe and getting the best results.


Final Thoughts

Biote hormone therapy has helped many people feel better by bringing their hormones back into balance. It may result in fewer adverse effects because it uses natural, bioidentical hormones that are tailored to your body's requirements. and more consistent results.



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