Beyond Fillers: Discover Profhilo and Polynucleotides for Ultimate Skin Rejuvenation in Rotterdam

Written by De Gezichtskliniek  »  Updated on: June 10th, 2025

 Beyond Fillers: Discover Profhilo and Polynucleotides for Ultimate Skin Rejuvenation in Rotterdam

While Botox and traditional dermal fillers excel at smoothing wrinkles and restoring lost volume, the landscape of aesthetic medicine continues to evolve, offering even more sophisticated solutions for comprehensive skin rejuvenation. At De Gezichtskliniek Rotterdam, located in the heart of Rotterdam Centrum, we are proud to offer advanced treatments like Profhilo and Polynucleotides (Zalm Sperma). These innovative injectables work on a deeper, cellular level to improve skin quality, texture, and elasticity, going "beyond fillers" to truly revitalize your complexion from within.


We believe that looking your best involves not just addressing lines and volume, but nurturing the very health of your skin. Our experienced, BIG-registered doctors specialize in these cutting-edge treatments, providing professional care at affordable prices, making advanced skin rejuvenation accessible to everyone in Rotterdam.


Profhilo: The Injectable Moisturizer for Deep Skin Hydration and Firmness

Often referred to as an "injectable moisturizer" or a "bio-remodelling agent," Profhilo stands apart from traditional fillers. While conventional fillers add volume to specific areas, Profhilo's primary function is to hydrate the skin from within and stimulate the natural production of collagen and elastin – the scaffolding proteins that keep our skin firm and supple.


What is Profhilo?

Profhilo is an injectable skin treatment with a remarkably high concentration of pure hyaluronic acid. Unlike the cross-linked hyaluronic acid used in dermal fillers, Profhilo's unique molecular structure allows it to spread smoothly and evenly throughout the skin after injection. This ensures a uniform distribution of its hydrating and stimulating properties across a wider area, rather than creating localized volume.


How Does Profhilo Work?

Once injected, Profhilo acts as a hydrator, drawing water into the skin to improve its internal moisture. More importantly, it triggers a bio-remodelling process. The specialized hyaluronic acid slowly releases over several weeks, stimulating fibroblasts, keratinocytes, and adipocytes (skin cells) to produce new collagen and elastin. This stimulation leads to:


Improved Skin Texture: Skin becomes smoother and more refined.

Enhanced Elasticity: The skin regains its bounce and flexibility.

Increased Firmness: A noticeable lifting and tightening effect as the skin's internal structure is rebuilt.

Overall Skin Rejuvenation: A global improvement in skin quality, giving a fresh, youthful glow.

Ideal Candidates for Profhilo

Profhilo is ideal for individuals experiencing skin laxity, dullness, fine lines, and crepey skin, particularly on the face, neck, decolletage, and hands. It's an excellent choice for those seeking overall skin quality improvement rather than specific volume correction. Its natural spreading capability makes it perfect for a subtle, natural rejuvenation that enhances your inherent beauty.


At De Gezichtskliniek Rotterdam, a Profhilo treatment is offered at a competitive price of €250, providing an affordable entry into this advanced skin revitalization.


Polynucleotides (Zalm Sperma): Cellular Regeneration for Natural Rejuvenation

Polynucleotides represent another significant leap forward in aesthetic medicine, offering regenerative benefits that work at the cellular level to rejuvenate and repair the skin. Often referred to as "Zalm Sperma" due to their origin, these treatments are gaining rapid popularity for their ability to promote deep tissue repair and collagen synthesis.


What Are Polynucleotides?

Polynucleotides are specialized injectable solutions derived from purified DNA fragments, typically from salmon. These fragments are biocompatible and safe, acting as powerful bio-stimulators within the skin. They are not fillers in the traditional sense, as they do not add volume. Instead, their magic lies in their ability to awaken the skin's inherent repair mechanisms.


How Do Polynucleotides Work?

Once introduced into the skin, Polynucleotides interact directly with skin cells to:


Stimulate Fibroblast Activity: Fibroblasts are the key cells responsible for producing collagen and elastin. Polynucleotides significantly boost their activity, leading to increased production of these vital proteins.

Promote Tissue Repair: They aid in the repair of damaged skin cells and tissues, making them excellent for addressing scarring and compromised skin.

Improve Hydration and Antioxidant Protection: They also contribute to better hydration and provide antioxidant protection, combating oxidative stress that can lead to premature aging.

Targeted Benefits of Polynucleotides

Polynucleotides are particularly effective for treating:


Fine Lines: Softening delicate lines for a smoother complexion.

Acne Scars: Promoting repair and regeneration to improve the appearance of scarring.

Delicate Skin Zones: Highly effective for sensitive areas like under the eyes, where traditional fillers might not be suitable, providing a natural rejuvenation for tired-looking eyes.

Overall Skin Quality: Leading to enhanced skin elasticity, firmness, and a radiant glow.

At De Gezichtskliniek Rotterdam, Polynucleotides treatments are available for €225, making this cutting-edge cellular rejuvenation an accessible option for those seeking profound skin health benefits.


Why Choose De Gezichtskliniek Rotterdam for Advanced Skin Rejuvenation?

Choosing the right clinic for advanced treatments like Profhilo and Polynucleotides is crucial. At De Gezichtskliniek Rotterdam, we combine expertise, affordability, and a client-focused approach to ensure your experience is exceptional:


Experienced BIG-Registered Doctors: All our skin injectable treatments, including Profhilo and Polynucleotides, are performed exclusively by our highly qualified BIG-registered doctors. This ensures the highest standards of safety, precise injection techniques, and a deep understanding of skin biology to deliver optimal and natural results. Our team, including names like Eliza van Twisk, Beyza Erdal, and Sebastiaan Wermenbol, are dedicated to your care.

Commitment to Quality & Safety: We utilize only the best products and adhere to the latest and safest injection methods. Our thousands of treatments performed annually across all our services speak to our rigorous standards and successful outcomes.

Unbeatable Affordability: We pride ourselves on offering some of the lowest prices in the Netherlands for advanced aesthetic treatments. This commitment to affordability means you don’t have to compromise on the quality of your care to achieve your skin goals. Our transparent pricing for Profhilo (€250) and Polynucleotides (€225) demonstrates this commitment.

Personalized Approach: Every treatment journey begins with a thorough consultation. Our doctors take the time to understand your unique skin concerns and aesthetic aspirations, crafting a personalized treatment plan that leverages the unique benefits of Profhilo, Polynucleotides, or a combination of therapies to achieve the most beautiful result for you.

Your Journey to Radiant Skin Starts Here

If you’re seeking a deeper level of skin rejuvenation that goes beyond traditional solutions, Profhilo and Polynucleotides at De Gezichtskliniek Rotterdam offer powerful, natural-looking results. Whether you want to improve overall skin texture, firmness, elasticity, or target specific concerns like fine lines and under-eye delicacy, our expert team is here to guide you.


We invite you to book a free consultation in our boutique clinic in Rotterdam Centrum. This is a no-obligation opportunity to discuss your skin goals, understand the science behind these innovative treatments, and explore how we can help you achieve radiant, healthy-looking skin. Our clinic is open Monday to Friday (9:00 - 22:00) and Saturday to Sunday (10:00 - 18:00) for your convenience.


Connect with us via WhatsApp (24/7) at +31 85 130 68 18, email [email protected], or simply book online. Discover the transformative power of advanced skin rejuvenation at De Gezichtskliniek and unveil a more confident, luminous you.


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